Take the first round of turns. The first player begins by flipping over the top card in his or her stockpile. The player then draws five cards from the draw pile. Depending on the player's hand, he or she then chooses one of the following options:
If the player has a 1 or a Skip-Bo wild card in his or her hand or at the top of his or her stockpile, the player is allowed to start a build pile. Each build pile is the beginning of a sequence, and the pile is "built" when more cards are added in sequential order - a 2, a 3, a 4, and so on. Gaps in the sequence may be filled in by Skip-Bo wild cards. The player continues to build until he or she no longer has any cards left to keep building the sequence, then discards one card to form a discard pile before ending his or her turn.
If the player doesn't have a 1 or a Skip-Bo card, the player discards one card to form his or her first discard pile. Up to four discard piles can be formed in subsequent turns.
Have the second player take a turn. The second player turns over the top card in his or her stockpile, draws five cards from the draw pile, and continues in the same fashion described above to either build a new pile, add to an existing pile, or simply discard a card.