CONCLUSION
These data suggest that aerobic exercise is associated with
a reduced risk of cognitive impairment and dementia; it
may slow dementing illness. A compelling argument can
be made for this via 2 plausible biologic pathways. Eirst,
a convergence of evidence from both animal and human
studies suggests that aerobic exercise may attenuate progression
of neurodegenerative processes and age-related
loss of synapses and neuropil. This may occur via a direct
infiuence on neurodegenerative disease mechanisms
or facilitation of neuroprotective neurotrophic factors and
neuroplasticity. Not to be overlooked, however, is a second
pathway, cerebrovascular disease. Cerebrovascular burden
contributes to dementia risk, especially via small vessel disease
(eg, lacunes and leukoaraiosis). Vascular risk factors
are well known to be reduced by aerobic exercise. Thus,
ongoing, moderate-intensity physical exercise should be
considered as a prescription for lowering cognitive risks
and slowing cognitive decline across the age spectrum.
CONCLUSION
These data suggest that aerobic exercise is associated with
a reduced risk of cognitive impairment and dementia; it
may slow dementing illness. A compelling argument can
be made for this via 2 plausible biologic pathways. Eirst,
a convergence of evidence from both animal and human
studies suggests that aerobic exercise may attenuate progression
of neurodegenerative processes and age-related
loss of synapses and neuropil. This may occur via a direct
infiuence on neurodegenerative disease mechanisms
or facilitation of neuroprotective neurotrophic factors and
neuroplasticity. Not to be overlooked, however, is a second
pathway, cerebrovascular disease. Cerebrovascular burden
contributes to dementia risk, especially via small vessel disease
(eg, lacunes and leukoaraiosis). Vascular risk factors
are well known to be reduced by aerobic exercise. Thus,
ongoing, moderate-intensity physical exercise should be
considered as a prescription for lowering cognitive risks
and slowing cognitive decline across the age spectrum.
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