Infection with smallpox is focused in small blood vessels of the skin and in the mouth and throat before disseminating. In the skin it results in a characteristic maculopapular rash and, later, raised fluid-filled blisters. V. major produced a more serious disease and had an overall mortality rate of 30–35 percent. V. minor caused a milder form of disease (also known as alastrim, cottonpox,milkpox, whitepox, and Cuban itch) which killed about 1 percent of its victims.[6][7] Long-term complications of V. major infection included characteristic scars, commonly on the face, which occur in 65–85 percent of survivors.[8] Blindness resulting from corneal ulceration and scarring, and limb deformities due to arthritis and osteomyelitis were less common complications, seen in about 2–5 percent of cases.