Granulate characteristics are shown in Table 2. The mean particle size of Met granulates produced with VA64 (added water 1.0%, 75 μm; 1.5%, 164 μm) and HPC (added water 1.0%, 111 μm; 1.5%, 152 μm) increased with increasing volume of added water. The PVP Met granulates had similar sizes (136 μm) when made with either 1.5% or 2.0% added water, which might not have an impact on the granule enlargements. The volume of water for granulation may have been too low for the HPMC Met granulates, which may be why the particles were smaller than other formulations.