1. Acute oral toxicity study in rat (2g/kg)
2. 90 day Sub-chronic oral toxicity study in rat (2g/kg)
3. Mutagenicity study
・Ames tests (2.5 g/kg)
・Chromosomal aberration test in CHO cells (0.313 mg/ml)
・Micronucleus test in rat (2g/kg)
4. Human safety study
・28 day oral study (2.5 g/day/man, n = 11)
・14 week oral study (500 mg/day/man, n = 25)