From a practice perspective, the study’s findings lend support for nurses and other healthcare professionals to be more vigilant in assessing and managing children’s symptom experiences. Successful care of children with cancer requires a comprehensive assessment; all symptoms warrant attention by nurses regardless of patients’ degree of distress. Therefore, all those caring for children with cancer must be cognizant of and consider all of the children’s symptom experiences. Even if children and families do not complain of any symptoms, nurses should inquire about the absence or presence of potential symptoms. Anticipatory guidance is key to symptom management. Nurses need to be careful and thorough in their assessments of children’s symptom experiences, especially considering the children in this study found that rating their symptoms on any type of self-assessment scale was not always helpful. Relying solely on self-assessment scales limits understanding of what children may be feeling and may not be able to truly capture the children’s suffering. During the assessment process, healthcare providers must ascertain the beliefs and expectations of children and families in relation to symptom experiences and symptom containment. Obtaining a comprehensive assessment is the first step for nurses to promote the attitude of “it really helps” and not “it sort of helps” with respect to symptom management in children with cancer. Nurses must reinforce to families that suffering in relation to symptom distress should not be perceived as a requisite to overcoming cancer. Nurses should work with families and children in easing their suffering. This includes nurses becoming aware of strategies used by children and families to relieve symptoms. Integrating nurse-initiated symptom relief strategies with child- and family-initiated strategies will result in a more comprehensive approach to symptom containment.