1. Introduction
Rheumatoid Arthritis (RA) is a disease, which
is a common, chronic, systemic, autoimmune
inflammatory disease in nature that mainly
affects the joints of the body; basically fingers,
hands, knees and cause disability, premature
morality and chronic ill-health [1]. It targets
synovial joints, in which there is a massive
accumulation of blood-borne cells such as T
cells and macrophages. Blood vessels are
formed to support this new tissue and the whole
mass is called a pannus progressive erosion to
cartilage and bone leads to disability in
patients. RA affects about 0.5% – 1% of the
population (ratio of female to male patients is
about 3:1).Mainly after the third year of the
start of the 75% of all patients get disabled [2].
The life expectancy of a patient is reduced by 4
– 10 years. Till today there is no proven cure
for the disease, hence close monitoring of the
disease is important in medical treatment of the
disease. There are various methods available
for treatment of the +disease, among which
Joint damage assessment in hand radiographs is
the most frequently used method [2].
Additionally, the sensitive biomarkers of the
disease progression are being developed, so
that the performance of the candidate disease
by the modifying drugs can be quantified in a
short period of time [3].
Signs and Symptoms of Rheumatoid
Arthritis (RA): Since Rheumatoid Arthritis
mainly occurs in the joints of the body, so it
includes the problems involving the other
organs of the body [4].
During the last two decades, traditional
techniques such as bone ultrasound
scintingraphy, contrast enhanced and most
recently used MR, mainly contrast enhanced
MR, and was used in two ways: firstly for
theearly diagnosis, and secondly for assessing
the effectiveness of the often and the expensive
toxic therapies. However, on clinical
background MR remains incompletely accepted
[5] [6]. The major limitations encountered in
early work were its large size of sensors, low
resolution, and the limited power of computers
for the image post processing [7]. The use and
development of imaging biomarkers are now
becoming more critical and important in the