Resistance of STIs-in particular gonorrhoea-to antibiotics has increased rapidly in recent years has reduced treatment options. The emergence of decreased susceptibility of gonorrhoea to the "last line" treatment option (oral and injectable cephalosporins) together with antimicrobial resistance already shown to penicillins, sulphonamides , tetracyclines , quinolones and macrolides make gonorrhoea a multidrug-resistant orgenism. Antimicrobial resistance for other STIs, though less common , also exists, making prevention and prompt treatment critical.