In North America and Europe, this emigration pattern resulted in the
manifestation of clinical phenotypes, many involving -thalassemia mutations that were previously less
often recognized
The North American cross-sectional study identified 132 patients out of a total of 721
analyzed (18%) with clinically significant -thalassemia syndromes[4]. This high incidence should spur
more efforts to develop programs for newborn and prenatal screening, and for understanding genotypephenotype
correlations