A wide array of causes may impair thermoregulation. In general, the end result is failure of the hypothalamus to regulate core body temperature, often as a result of direct effects on the central nervous system. Examples where this occurs include brain and spinal cord trauma, stroke, intracranial haemorrhage, central nervous system tumours, Parkinson's disease, Wernicke's encephalopathy, and multiple sclerosis. Sepsis and uraemia may also alter the hypothalamic set point resulting in hypothermia.