Clinical symptoms, which vary from fecal
urgency
and diarrhea to cessation of bowel movements in toxic
megacolon,
are caused by C. difficile enterotoxins that damage
the
colonic mucosa and produce inflammation. Common clinical
challenges
associated with CDI include recurrent infection (RCDI),
severe
or
complicated
infection refractory to antibiotic therapy, and
CDI
associated with underlying inflammatory bowel disease (IBD).
FMT
appears
to be effective in all these presentations, but there are
important
nuances associated with each.