The percentage of entry and time spent in the closed arm produced by CPPE 100 mg/kg were not significant compared to diazepam 1 mg/kg and these results are similar with the other reports (Rabbani et al., 2003) and it could be due to increased entry and time in the open arms by the mice and this para- meter can further support the anxiolytic activity of the Carica papaya pulp extract. Of the four doses of CPPE used in this study, 100 mg/kg was found to the effective dose for the treatment of anxiety in the male mice model of EPM and it also showed better pro fi le on the percent time spent on the open arm entry (54.29%) compared to diazepam (45.18%) with comparable effect on the percentage of open arm entries. From this we could say that CPPE at 100 mg/kg has a better anxiolytic activity than oral diazepam (1 mg/kg).