The waste in experimental animals, the prohibition of valuable individual chemicals or substances {e.g. DDT [1,1 bis (p-chlorophenyl) 2,2,2 trichloroethane]}, the amount of time spent in investigating effects that emerge to be relevant only to experimental animals, together with the different practices of regulatory authorities, identify a need to establish a more
relevant paradigm for establishing the maximum dose to which animals should be exposed.