mathematical modeling is a hallmark
of such mechanistic studies.
Although this study does not provide extensive time-course information,
dose–response behaviors are the result of kinetic molecular mechanisms that also produce dynamic behavior.
For example, one recent study explored the mechanisms by which TLR ‘signal encoding’ is thresholded and identified the formation of an oligomeric signalosome, the Myddosome, as a source of this ultrasensitivity