Research into metal-NP-based electrochemical detection for bioanalysis has drawn increasing attention from scientists in recent years owing to their extreme usefulness. Many types of metal NPs with different sizes and compositions are now available, facilitating their use in electrochemical applications as both chemical sensors and biosensors. These metal-NPs are of high surface area, high mechanical strength but ultra-light weight, rich electronic properties, and excellent chemical and thermal stability [13]. The unique properties of nanoscale materials led to very high sensitivity that is a gold purpose in biological assays. Currently, highly