Despite the effectiveness of SCIT in children, new
treatment modalities have emerged due to the discomfort
(repeated injections) and risk of life-threatening adverse
effects associated with subcutaneous administration. SLIT,
for instance, which involves applying allergen extract to the
mucosal surfaces of the immunologically rich sublingual area,
has been accepted as a safe SIT method. Both SCIT and SLIT
can reduce the duration and dose of inhaled corticosteroids and
even lead to their successful discontinuation in the long-term
treatment of HDM-induced asthma/rhinitis