The classic clinical picture of ZIKV infection resembles that of dengue fever and
chikungunya and is manifested by fever, headache, arthralgia, myalgia, and
maculopapular rash, a complex of symptoms that hampers differential diagnosis.
Although the disease is self-limiting, cases of neurologic manifestations and the
Guillain–Barré syndrome were described in French Polynesia and in Brazil during
ZIKV epidemics.5,6 Recent reports from the Ministry of Health of Brazil suggest
that cases of microcephaly have increased by a factor of approximately 20 among
newborns in the northeast region of the country, which indicates a possible association
between ZIKV infection in pregnancy and fetal malformations.5
We present a case of vertical transmission of ZIKV in a woman who was prob-ably infected with ZIKV in northeastern Brazil at
the end of the first trimester of pregnancy. Our
discussion includes details of fetal imaging and
pathological and virologic analyses.