Isolated phytosterols, namely lophenol and cycloartanol, have
the ability to induce the downregulation of fatty acid synthesis and
a tendency for upregulation of fatty acid oxidation in the liver,
which favors the reduction in intra-abdominal fat and improvement
of hyperlipidemia. Further, addition to sterol regulatory
element-binding transcription factor 1/peroxisome proliferatoractivated
receptor (PPAR)-a ratio was decreased; metabolic
syndrome-related disorders were improved and liver steatosis in
Aloe-sterol-treated Zucker diabetic fatty rats