Effect on bleeding time
The tail transection bleeding time was determined according
to the method of Dejana et al. (41) Male C57BL/6 mice were
fasted overnight and curcumin or BDMC was administered orally
to mice. One hour after administration, the mouse tail was
transected at 2 mm from the tip. Bleeding time was measured
as time elapsed until bleeding stopped. When bleeding time
lasted longer than 15 min, measurement was stopped and
bleeding time was recorded as 15 min for statistical analyses