This study has shown us that cellulosic waste obtained from cassava tubers after starch processing can be utilized for the production of bioethanol. Pretreatment of the waste with HCl and simultaneous hydrolysis at conditions of pH 6.9, temperature 100 C, time 1h (amylase) produces more disaccharide. Subsequent saccharification with amyloglucosidase at pH 4.6, temperature 55 C, and time 20 h have enabled the exploitation of these waste materials thereby producing more glucose for fermentation. During fermentation within the first three hours there was a tremendous depletion of sugar followed by a slow rate in the next eight hours and thereafter, though there was still reducing sugar but may not be sufficient for consumption by the growing yeast cells. In summary, the yield of alcohol obtained in this study is low and comparison with related studies has shown that the yield here is slightly higher. The integration of 2G ethanol with 1G could facilitate the better utilization of the biomass and relatively relax the economics of production. A further study on sugar cane and its wastes is ongoing to establish the economy of the process and variation of parameter for efficient biofuel yield and large scale production. Besides, the major interest is to modify the sugar cane genetica