However, when the 10 to 1 (by
weight) phospholipid/MPOC
mixture was incubated with
cell-sized liposomes, rhodamine fluorescence signals could not
at all be observed inside the liposomes. The results imply that a
high amount of phospholipid on the MPOC surface can
suppress the lipid bilayer membrane penetration ability of the
particles. This excellent ability of MPOCs to adsorb
phospholipids also agreed well with the above FRET result
and our observation that the MPOCs always instantly moved to
the surface of the liposomes. All these results suggest that
MPOC possesses high phospholipid affinity, and the particle’s
ability to induce leakage on lipid bilayer membrane may
involves its phospholipid adsorption. It should be noted here
that this is not the first report on the interaction between
carbon-based materials and lipid bilayer membrane.
RhB