Spilanthes acmella, a well known antitoothache plant with high medicinal usages, has been
recognized as an important medicinal plant and has an increasingly high demand worldwide.
From its traditional uses in health care and food, extensive phytochemical studies have been
reported. This review provides an overview and general description of the plant species, bioactive
metabolites and important pharmacological activities including the preparation, purification
and in vitro large-scale production. Structure-activity relationships of the bioactive
compounds have been discussed. Considering data from the literature, it could be demonstrated
that S. acmella possesses diverse bioactive properties and immense utilization in medicine,
health care, cosmetics and as health supplements. As a health food, it is enriched with high
therapeutic value with high potential for further development