Issues such as ‘cruelty’ to animals and the humane treatment of animals are valid concerns, and hence, the use of animals in experimentation is greatly regulated. This has led to the 3Rs campaign, which advocates the search (1) for the replacement of animals with non-living models; (2) reduction in the use of animals; and (3) refinement of animal use practices. However, total elimination of animal testing will significantly set back the development of essential medical devices, medicines, and treatment. By employing the 3Rs when continuing to use animals for scientific research, the scientific community can affirm its moral conscience as well as uphold its obligation to humanity to further the advancement of science for civilization and humanity.