Pathogenesis of ZIKV is almost unknown; however, it is found that mosquito-borne flaviviruses initially replicate in dendritic cells close to the inoculation site and then spread to lymph nodes and the blood. Although flaviviral replication is found to occur in cellular cytoplasm, studies suggest that ZIKV antigens can be found in nucleus of the infected cells. Moreover, infectious ZIKV has been detected in human blood before the beginning of symptoms[15].