including acetaminophen, non-steroidal anti-inflammatory gels, wearing a supportive and well-fitted brassiere have been used in the treatment of mastalgia [9]. Unfortunately, there isn’t any curative treatment today. In this paper, we evaluated the efficacy of three different therapeutic options including evening primrose oil (EPO), Fructus Agni Casti (FAC) and reassurance, in the patients with breast pain