Reports on the mechanism of inhibitory action of silver ions on microorganisms have shown that upon treatment with Ag DNA loses its ability to replicate resulting in inactivated expression of ribosomal subunit proteins,as as well as certain other cellular proteins and enzymes essential to ATP production. It has also been hypothesized that Ag+ primarily affects the function of membrane-bound enzymes, such as those in the respiratory chain. In summary, AgNPs exerted potent antifungal effects on fungi tested in vitro, probably through destruction of membrane integrity; therefore, it was concluded that AgNPs have considerable antifungal activity. Further investigation for field applications is needed.