of statin therapy at high dosage, such asmyopathy and myalgia, that are
a major cause of discontinuation of lipid-lowering therapy [29].
Nevertheless, beyond the clear anti-hyperlipidemic effect of the
nutraceutical, themechanism of action of the single substances remains
to be elucidated, as well as the possible synergistic effect of the natural
active ingredients within the formulation.
Several studies describe the cholesterol lowering effect of plant sterols
and plant stanols, by reducing intestinal absorption of exogenous
cholesterol [30]