Then his clinical status suddenly deteriorated
and the blood leukocyte count increased to 45,000. At that time, half
of the proliferating cells in the bone marrow, lymph nodes, and blood were
typical lymphoblasts (Fig. 1). The patient died shortly afterwards in spite of
combined chemotherapy. Immunofluorescence study demonstrated the presence
of the same 1gM K molecules with a well defined anti-IgG antibody
activity (see below) on both lymphocytes and lymphoblasts.