Different dynamics in the HSP70 concentration in
lymphocytes during gestation in primiparous and
pluriparous cows suggest that the occurrence of a
previous gestation may be a factor influencing how the
immune system of a cow handles pregnancy. The effect
of age on HSP expression has been studied in the serum
of nonpregnant women. Rea et al. [30] found that the
ability of cells to respond to stress and synthesize HSP
decreases with increasing age, whereas in a recent
study, Molvarec et al. [13] did not find a negative
correlation between age and HSP70 concentrations in
serum, perhaps due to the narrower age range in this
study. Furthermore, HSP concentrations in lymphocytes
and in serum cannot be directly extrapolated, because
there are, for example, indications that intracellular but
not extracellular concentrations of HSP72 increase in
physiologically stressed humans [8].
Different dynamics in the HSP70 concentration inlymphocytes during gestation in primiparous andpluriparous cows suggest that the occurrence of aprevious gestation may be a factor influencing how theimmune system of a cow handles pregnancy. The effectof age on HSP expression has been studied in the serumof nonpregnant women. Rea et al. [30] found that theability of cells to respond to stress and synthesize HSPdecreases with increasing age, whereas in a recentstudy, Molvarec et al. [13] did not find a negativecorrelation between age and HSP70 concentrations inserum, perhaps due to the narrower age range in thisstudy. Furthermore, HSP concentrations in lymphocytesand in serum cannot be directly extrapolated, becausethere are, for example, indications that intracellular butnot extracellular concentrations of HSP72 increase inphysiologically stressed humans [8].
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