Johnny Depp as Dr. Will Caster, an artificial-intelligence researcher.
Rebecca Hall as Evelyn Caster, Will's wife and a fellow academic.
Paul Bettany as Max Waters, Will's best friend.
Kate Mara as Bree, the leader of Revolutionary Independence From Technology (R.I.F.T.)
Cillian Murphy as Donald Buchanan, an FBI agent.
Cole Hauser as Colonel Stevens, a military officer.
Morgan Freeman as Joseph Tagger, an FBI agent and old friend of Evelyn.
Clifton Collins, Jr. as Martin
Cory Hardrict as Joel Edmund, a member of the R.I.F.T. Unit.
Josh Stewart as Paul
Falk Hentschel as Bob, a member of the R.I.F.T.