In summary, our data of electrophysiological study provides enough evidence for visual cortex hyper-excitability in migraine with and without aura. Furthermore, in therapeutic study, inhibitory tDCS over the occipital cortex was effective for migraine prophylaxis with regard (i) to reduce the painkiller intake, when compared with sham stimulation and (ii) to decrease the number of migraine attacks and average duration of each migraine attack, when compared to baseline condition, but unable to normalize the abnormal cortical hyper-excitability. It suggests that the excitability level of visual cortex neurons in migraine cannot drive appropriate brain stimulation protocol. These results should be replicated and confirmed with wider samples before being considered in clinical decision making.