A proposed model of cooperation between H-Ras and galectin-1 for radioresistance.
Galectin-1 enhances activation (GTP form) of H-Ras following irradiation.
Galectin-1 potentiates downstream signals of H-Ras, such as Raf-1 and ERK, that may mediate DNA damage repair33 and radioresistance.
31, 32 Galectin-1 may regulate p21 expression36 through Raf-1.34 Hence, Raf-1 may have a significant role in galectin-1-mediated radioresistance