Consequently, column backpressure is substantially reduced allowing higher flow rates and faster throughputs. Monolith sol-gel columns show good separation performance at lower pressures, a critical feature that is integral to the SIChrom performance. Monolithic columns that use reverse phase are most popular and they have found many applications including separation of pharmaceuticals, proteins, oligonucleotides, organic acids, and enantiomeric compounds. Monoliths with ion exchanger sites found application in ion chromatography.