In the present study we focus on the need for the alternative sources of the antibiotics as the pathogenic microbes
are gaining resistance against standard antibiotics. Cold Aqueous, Methanol, Ethanol, Ethyl Acetate extracts of
leaves of Carissa carandas in a final concentration of 500 mg/ml were evaluated for their antibacterial properties
against some selected pathogenic microorganisms such as Pseudomonas aeruginosa, Staphylococcus aureus and
Escherichia coli using agar well diffusion method. Methanolic, Ethyl Acetate and Ethanolic extracts of Carissa
carandas leaves show an average inhibitory zone diameter of 23.5, 22.0 and 21.5 mm respectively which indicate
that the Methanolic extract has shown the best result having Zone of Inhibition greater than that of the standard
antibiotic Tetracycline (17.0 mm).