After 96 h, lycopene significantly changed the cell viability in all cell lines. Lycopene treatment inhibited cell viability of MCF-7 and MDA-MB-235 cells by 30% and 20%, respectively (Figure 1A, 1B). However, MDA-MB-231 cells were inhibited by 75% with this compound (Figure 1C). Taken together, these data indicate that the effect of lycopene is cell-specific and time-dependent, and this effect requires a relatively long incubation time for the majority of breast cell lines studied to achieve better action.