Several small studies and case series have demonstrated favorable obstetrical and fetal outcome in
patients with b-thalassemia major when close followup and intensive treatment are instituted [6–9]. Less is known about pregnancy performance in patients with TI [6,8]. This entity encompasses a wide clinical spectrum. These patients usually have a disease the severity of which is somewhere between the mild manifestations of thalassemia trait and the severe symptoms of thalassemia major. Our series, one of the largest of patients with TI, shows that these pregnancies may have complicated antepartum and postpartum courses. IUGR complicates 57.1% of pregnancies. Transfusions, with their potential complications, are needed in most cases, and splenectomy may be indicated postpartum in a few patients.
Several small studies and case series have demonstrated favorable obstetrical and fetal outcome inpatients with b-thalassemia major when close followup and intensive treatment are instituted [6–9]. Less is known about pregnancy performance in patients with TI [6,8]. This entity encompasses a wide clinical spectrum. These patients usually have a disease the severity of which is somewhere between the mild manifestations of thalassemia trait and the severe symptoms of thalassemia major. Our series, one of the largest of patients with TI, shows that these pregnancies may have complicated antepartum and postpartum courses. IUGR complicates 57.1% of pregnancies. Transfusions, with their potential complications, are needed in most cases, and splenectomy may be indicated postpartum in a few patients.
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