Anxiety and depression in adolescents are a significant public health problem that may lead to serious and chronic mental disorders later in life. The present study was undertaken to better understand biological mechanisms that may underlie development of anxiety and depression in adolescents by looking for a possible link between these disorders and immunoglobulins (Ig)-reactive with ghrelin, a pleiotropic peptide hormone from the stomach, which has also been implicated in the regulation of internalizing behavior and physiological stress responses (Delporte, 2013).