In those experiments, anorectic activity and reversal of diabetes are maintained for the duration of dosing, up to 8 weeks; other studies demonstrate that the food inhibition and weight loss are independent of diet nutrient content and also occur in animals who overfeed on a highly palatable diet (Pytopharm and Pfizer, unpublished). Animal safety studies do not demonstrate deleterious effects independent of the weight loss itself. In addition, Phytopharm has recently disclosed short-term studies in humans, during which the plant extract was well tolerated.