With the emergence of resistant HSV in the immunocompromised, the typical treatment have also included foscarnet, ganciclovir, and vidarabine. There drugs have multiple toxic side effecs, leading to a continued effort to acquire new treatment. Several new nucleoside analogues are currently in clinical trials. Sorivudine, lobucavir, and cidofovir have promising profiles (Cassady & Whitley, 1997). Many of the newer approaches to HSV and have thr potential for highly efficient selectivity. Immunotherapies such as viral vaccines have promising research data (Spector et. al, 1998).