Conclusion
This pooled competing risks individual-level reanalysis of the
CORONA and GISSI-HF trials demonstrated a statistically significant,
though modest, reduction in risk for MI among patients with
ischaemic aetiologies of heart failure. This is the first analysis of
pooled data from large-scale trials of statins in heart failure patients
to demonstrate a significant reduction in MI. The absolute reduction
in risk for MI with rosuvastatin is relatively low in heart failure
patients in the context of their substantial risks of death from other
causes. These results are hypothesis generating for future studies
that may inform guidelines for heart failure and lipid management
given the current absence of recommendations for statin therapy
in heart failure patients.