Abstract: Background: The purpose of this preliminary study was to assess the in vivo performance of synthetic, cotton
wool-like nanocomposites consisting of a biodegradable poly(lactide-co-glycolide) fibrous matrix and containing either
calcium phosphate nanoparticles (PLGA/CaP 60:40) or silver doped CaP nanoparticles (PLGA/Ag-CaP 60:40). Besides
its extraordinary in vitro bioactivity the latter biomaterial (0.4 wt% total silver concentration) provides additional
antimicrobial properties for treating bone defects exposed to microorganisms.