e scientific research supporting the safety and benefits of monosodium glutamate (MSG) is extensive. Also, the scientific consensus among experts who have objectively studied MSG – and affirmed its safety – continues to grow. Despite this, there are some claims, often circulated on the Internet without any scientific or medical support, that MSG can cause certain side effects or symptoms. Here are the facts, based on the science evaluating this popular food ingredient that has been used safely in foods for more than a century.
Because monosodium glutamate is used widely as a food ingredient, a great deal of reputable research has been completed on its safety and efficacy. In fact, literally hundreds of trustworthy scientific studies have been conducted on glutamate with a focus on its use as a food ingredient (monosodium glutamate).
This extensive body of research has been reviewed by scientists and regulatory authorities around the world including the Joint Committee on Food Additives (JECFA) of the United Nations Food and Agriculture Organization and the World Health Organization, the EU Scientific Committee for Food (SCF) and the United States' Food and Drug Administration (FDA). All of these authorities have concluded that MSG is safe.
Claims (Myths) about MSG Explained – and Refuted – Based on Credible Science
1. Claim: MSG causes “Chinese Restaurant Syndrome” (CRS).
Fact: Careful, double-blind clinical research shows no side effects of MSG among people who claim MSG sensitivity. The research shows that people who claim to suffer from Chinese Restaurant Syndrome simply cannot isolate glutamate as the cause and often find that it is a well-known allergen such as peanuts, shellfish or certain herbs, which is causing the reaction.
2. Claim: MSG causes asthma.
Fact: Carefully designed studies show MSG does not cause asthma attacks.
3. Claim: MSG causes allergic reactions.
Fact: Carefully designed research shows MSG does not cause urticaria (hives or other allergic reactions). For example, a multicenter placebo-controlled study did not find any side effects when monosodium glutamate was given with food. Further, the American College of Allergy, Asthma and Immunology has stated that MSG is not an allergen.
4. Claim: MSG causes effects in the brain.
Fact: Innumerable studies show dietary MSG does not cause brain effects. Even in one study where plasma glutamate was raised 10-times above normal, which never occurs in real life, none of the glutamate entered the brain. This shows the effectiveness of the brain in being able to exclude glutamate from entering the brain.
5. Claim: MSG causes obesity.
Fact: Scientific research has shown that glutamate can be administered in very large doses to humans on a long-term basis with no ill effects. The intestinal metabolism of glutamate is no different whether the glutamate is derived from natural sources or from monosodium glutamate. The ingestion of MSG in the normal diet, even at very high amounts, does not raise plasma glutamate concentrations. This is because intestinal cells and liver cells metabolize almost all of the dietary glutamate as it is absorbed (they use it to make energy); the dietary glutamate never makes it into the body’s general circulation.
e scientific research supporting the safety and benefits of monosodium glutamate (MSG) is extensive. Also, the scientific consensus among experts who have objectively studied MSG – and affirmed its safety – continues to grow. Despite this, there are some claims, often circulated on the Internet without any scientific or medical support, that MSG can cause certain side effects or symptoms. Here are the facts, based on the science evaluating this popular food ingredient that has been used safely in foods for more than a century.Because monosodium glutamate is used widely as a food ingredient, a great deal of reputable research has been completed on its safety and efficacy. In fact, literally hundreds of trustworthy scientific studies have been conducted on glutamate with a focus on its use as a food ingredient (monosodium glutamate). This extensive body of research has been reviewed by scientists and regulatory authorities around the world including the Joint Committee on Food Additives (JECFA) of the United Nations Food and Agriculture Organization and the World Health Organization, the EU Scientific Committee for Food (SCF) and the United States' Food and Drug Administration (FDA). All of these authorities have concluded that MSG is safe.Claims (Myths) about MSG Explained – and Refuted – Based on Credible Science1. Claim: MSG causes “Chinese Restaurant Syndrome” (CRS).Fact: Careful, double-blind clinical research shows no side effects of MSG among people who claim MSG sensitivity. The research shows that people who claim to suffer from Chinese Restaurant Syndrome simply cannot isolate glutamate as the cause and often find that it is a well-known allergen such as peanuts, shellfish or certain herbs, which is causing the reaction.2. Claim: MSG causes asthma.Fact: Carefully designed studies show MSG does not cause asthma attacks.3. Claim: MSG causes allergic reactions.Fact: Carefully designed research shows MSG does not cause urticaria (hives or other allergic reactions). For example, a multicenter placebo-controlled study did not find any side effects when monosodium glutamate was given with food. Further, the American College of Allergy, Asthma and Immunology has stated that MSG is not an allergen.4. Claim: MSG causes effects in the brain.Fact: Innumerable studies show dietary MSG does not cause brain effects. Even in one study where plasma glutamate was raised 10-times above normal, which never occurs in real life, none of the glutamate entered the brain. This shows the effectiveness of the brain in being able to exclude glutamate from entering the brain.5. Claim: MSG causes obesity.Fact: Scientific research has shown that glutamate can be administered in very large doses to humans on a long-term basis with no ill effects. The intestinal metabolism of glutamate is no different whether the glutamate is derived from natural sources or from monosodium glutamate. The ingestion of MSG in the normal diet, even at very high amounts, does not raise plasma glutamate concentrations. This is because intestinal cells and liver cells metabolize almost all of the dietary glutamate as it is absorbed (they use it to make energy); the dietary glutamate never makes it into the body’s general circulation.
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