Furthermore, some small
chromosomal rearrangements in MM may be cryptic to
chromosome banding analysis. Thus FISH, which is
effective for analysis of interphase nuclei and small
chromosomal aberrations, is recognized as the most
robust genetic test for characterizing the known cytogenetic abnormalities in MM. Nevertheless, integration
of data from the multiple genetic profiling techniques
including CC, FISH, RT-PCR, and gene mutation analysis, among others, would provide comprehensive information for better stratification of MM patients with
diagnostic and prognostic significance