Treatment of the neuropathy depends on the underlying cause, if one is found. A significany median mononeuropathy at the wrist may benefit from surgical decompression. Optimal glycemic control may help improve diabetic polyneuropathy. Chronic weakness of the distal limbs may require braces, splints,or use of a cane or walker. Anklle-foot orthoses prevent tripping in the setting of foot drop. Whether or not a direct cause of polyneuropathy is found, many patients suffer from constant neuropathic pain in their feet. Topical capsaicin, a substance P depleter, or lidocaine patches can be applied over the involved skin. Effective oral medications for neuropathic pain include anticonvulsants (gabapentin, pregabalin, carbamazepine) and antidepressants (duloxetine, amitriptyline) which all interact with neurotransmitters.