In this paper, a kind of non-invasive cuff blood pressure monitoring system is designed and presented. This device provides a useful system for people to measure their daily blood pressure and achieve early diagnosis of hypertension. The pressure signal is collected by the pressure senor and this proposed design includes a ZigBee wireless transmission module, in order to send BP data to the Information System in real time. In addition, the structure of the system is designed to a portable low power consumption device which is convenient to operate especially for senior citizens. This monitoring system can also be extended into the platform for mobile telemedicine system, including ECG and blood oxygen monitoring system.