Blood clotting (fibrin) are physiologically formed by the actionof thrombin (EC 3.4.21.5) through fibrinogen [1]. Accumulationof fibrin in blood vessels usually increases arterial and/or venous thrombosis, which is one of the main causes of
cardiovascular dis-eases [2]. As fibrin can be hydrolyzed
by plasmin (EC 3.4.21.7),plasmin activators are used as a thrombolytic agent, includ-ing streptokinase (EC 3.4.99.0), urokinase (EC 3.4.21.73), tissueplasminogen activator (t-PA), and staphylokinase (EC 3.4.99.22).However, these agents are
expensive and can cause undesirableside effects, such as gastrointestinal bleeding, allergic reactions,and resistance to repercussion [3]. Therefore, thrombolytic
agentsfrom various sources have been continually sough. The microbial