The audience wants you to look at them. Therefore, look at the audience as much as possible.
But, don't fix your attention on one individual - it can be intimidating. Even looking at a select, few individuals only can also be intimidating (and annoying to others, especially if these persons are in the front row).
And whatever you do, DO NOT
Face the display screen behind you and talk to it.
Look at the computer screen and talk to that.
And, of course, reading a script is forbidden !