Flight caterers and airlines have an excellent record for food safety, especially considering that the business is characterised by a number of challenges-cook-chill production, time delay between production and consumption, and large-scale operations. Over the years, however, there have been a small number of outbreaks of food poisoning amongst passengers and crew. Clearly, the implications of a food poisoning outbreak to a business can be significant. Costs could include tracing the source of the outbreak, loss of business through loss of contracts with airlines, and paying compensation to airlines and/or passengers. It is a sad fact that most outbreaks of food poisoning are the result of a breakdown in good hygiene practices and could have been avoided. Patrick Wall, when Chief Executive of the Food Safety Authority (Ireland), encapsulated this beautifully when he said, "Food poisoning is not bad luck, it is bad management." This chapter defines safety hazards, reviews the nature and control of micro- organisms, gives a brief account of major food pathogens (micro-organisms causing illness), including examples of food poisoning cases associated with the flight catering industry, and concludes with a discussion of Hazard Analysis, Critical Control Points (HACCP). HACCP is the method widely advocated as the food safety management system of choice in the food industry, including the flight-catering sector.