As noted DSM-5 nominates a set of “significant losses” considered equally likely to generate responses which “resemble a depressive episode” (i.e. bereavement, financial ruin, serious medical illness, losses from a natural disaster). Our data included the first three events—with bereavement prioritizing a primary grief response for a first-degree relative and being a common grief response for a second degree relative. In both cases very low primary depression responses were quantified (3.6% in relation to loss of a family member and 4.6% in relation to loss of a family friend or other relative). Neither event had a significantly different response profile in depressed and non-depressed sub-sets. In contrast, both a financial crisis and a medical illness generated a primary stress response (73.2% and 36.1%, respectively), lower primary depression response rates (11.3% and 22.7% respectively) and extremely low primary grief responses (2.8% and 2.1%, respectively).