SFC with CO2 utilizes carbon dioxide pumps that require that the incoming CO2 and pump heads be kept cold in order to maintain the carbon dioxide at a temperature and pressure that keeps it in a liquid state where it can be effectively metered at some specified flow rate. The CO2 subsequently becomes supercritical post the injector and in the column oven when the temperature and pressure it is subjected to are raised above the triple point of the liquid and the supercritical state is achieved. SFC as a chromatographic process has been likened to a process having the combined properties of the power of a liquid to dissolve a matrix, with the chromatographic interactions and kinetics of a gas. The result is that you can get a lot of mass on column per injection, and still maintain a high chromatographic efficiency